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¹ Ege Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İzmir, Türkiye
² Lenkeran Devlet Üniversitesi, Fen Fakültesi, Biyokimya Bölümü, Lenkeran, Azerbaycan Viewed : 2063 - Downloaded : 973 Propolis, used to protect the colony from various bee diseases, to protect the airborne parts of the hive from viral, bacterial and fungal threats coming from the outside and to mummify the creatures so large that they can not be thrown away, is produced by honey bees after gathering from the shells of trees, buds and sprouts of plants. It is an apiteraphetic natural product which is generally yellow, green and brown, which does not dissolve in water, the color varies depending on the source and the age of the propolis. Its chemical structure is very compact, its major components are flavanoids, phenolic acids, glycosides and aglycons. The main actors of biological activity are flavanoids and phenolic acids. One of the major biological activities of phenols in propolisine structure is the strong antioxidant action by different pathways such as free radical cleansing properties, metal chelation and modulation of enzymatic activity. Reduces oxidative stress and prevents possible tissue and DNA damage. Propolis helps prevent inflammation by inhibiting the release of various mediators, inhibiting platelet aggregation and the synthesis of ezazonoids (prostaglandins and leukotrienes). Galangin and quercetin are the most active flavanoids in propolis in the prevention of infection. In addition to its beneficial side, it causes high allergic reactions and related disorders. For this reason, biotechnological transformation is required to reduce the allergic content and determine the dose range. Keywords : Propolis, Flavanoid, Oxidative stress, Antioxidant, Anti-inflammatory