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¹ Ege Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İzmir
² Lenkeran Devlet Üniversitesi, Fen Fakültesi, Biyokimya Bölümü, Lenkeran Viewed : 2144 - Downloaded : 1092 Propolis, which is used by bees for antiseptic and antibiotic properties, is a resinous material that is collected from the buds and secretions of plants and transformed with enzymes. Its physical structure is yellow, green and brown, which is softened by hot, sticky, aromatic smell, color gathering time, gathered resources and region. Although there are close to 300 chemical compounds in the chemical content, about 180 of them are defined. The main actors of biological activity are flavonoids and phenolic acids. Since the ages, propolis has been used in many cases of inflammation of the mouth and digestive tract, skin wounds, chronic inflammatory diseases and many other diseases. The active components of phenolic acids and flavanoids are of great importance for human health due to their different biological effects such as free radical scavenging properties, metal chelating and enzymatic activity modulation. Propolis has been proven to be an effective alternative against many cancer types such as head and neck, brain and spinal cord, blood, skin, breast, pancreas, liver, colon, prostate, kidney and bladder cancers as well as being one of the most important substances for human health. The antitumor properties of propolis are based on enhanced antioxidant status, enhanced immunosuppression, suppression of proliferation, reduction in cancer stem cell populations, blockage of specific oncogenic signaling pathways, antiangiogenesis, modulation of tumor micrococcus, development of chemotherapeutics and alleviation of side effects caused by these drugs. The efficacy of propolis in cancer prevention and cancer treatment is indisputable and its use at certain intervals can help prevent cancer. Keywords : Propolis, Flavanoid, Phenolic Acids, Cancer, Antitumor