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¹ Researcher, Directorate of Bee Research, The National Agricultural Research Center (NARC), 3 Amman, Jordan DOI : 10.51458/BSTD.2023.34 Viewed : 905 - Downloaded : 548 Honey nanoparticles have gained considerable attention in recent years for their potential applications in wound management. This article critically evaluates the current literature on honey nanoparticles and their unique properties, such as enhanced stability, bioavailability, and controlled release, while emphasizing the need for more targeted research in this area. The discussion explores honey's effectiveness in promoting wound healing, tissue regeneration, and antimicrobial activity, as well as the development of novel wound care products incorporating honey nanoparticles, like smart wound dressings, hydrogels, or topical ointments. The article concludes by highlighting the importance of comparative studies and exploring synergistic effects with other natural remedies to better understand the potential applications of honey nanoparticles in wound management. Ultimately, this comprehensive review aims to guide future research and clinical applications, paving the way for improved patient outcomes and innovative wound healing strategies. Keywords : Honey nanoparticles Wound management Wound healing Antimicrobial activity Nanotechnology